Cryoguard™ Thermal Exposure Indicators have been monitoring heat sensitive materials in real time for over 40 years. The indicators were originally developed to assure the quality of blood products being administered on the battlefield. They are now widely used to manage cold chains by quality conscious tissue banks as well as manufacturers of heat sensitive materials. Cryoguard Thermal Exposure Indicators eliminate the failure of medical procedures due to thermal exposure of transplant tissue. The indicators are currently used to verify that frozen eggs, sperm, cord blood, embryos, bone marrow, stem cells, bone grafts, blood plasma, vaccines, biologics, premixed adhesives and heat sensitive electronic components, were not thermally compromised during shipping, storage and handling by technicians and customs inspectors.
Product Name |
Signal Temperature |
Shipping/Storage Temperature |
-5°C |
-30°C or lower |
|
-15°C |
-40°C or lower |
|
-25°C |
-50°C or lower |
|
-40oC |
-65oC or lower |
|
-50°C |
-75°C or lower |
|
-70oC |
-95oC or lower |
|
-100oC |
-125oC or lower |
|
-120oC |
-145oC or lower |
|
-135oC |
-160oC or lower |
|
-150oC |
-175oC or lower |
At its signal temperature, a Cryoguard indicator irreversibly changes color from green to red in less than two hours. At 10°C to 15°C above its signal temperature the indicator changes color within minutes. At 25°C below its signal temperature the indicator remains green. Cryoguard indicators are available with “signal” temperatures as specified in the above table (click the Product Name for a detailed description). With a Cryoguard indicator monitoring your goods, you can tell in an instant (when the indicator is green) that the quality of your goods was never compromised by thermal exposure.
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By monitoring your goods with an indicator whose signal temperature is: a) equal to or lower than the maximum temperature designated for your goods and b) at least 25°C higher than the temperature used for shipping or storage, the indicator while green provides assurance that your goods are safe to use.
Cryoguard indicators eliminate the guesswork in deciding whether heat sensitive products are safe to use and provide a hassle-free alternative to a data logger.
Cryoguard LLC also provides Cryoguard freezer boxes. These boxes have openings on their sides for viewing indicators to facilitate verification that the material in the freezer box was never subjected to potentially damaging thermal exposure during handling, power failures and periods of coolant depletion.
For specimens stored in liquid nitrogen cooled containers, it is important to note that the temperature in a liquid nitrogen storage tank can vary from about -130°C at the top to -190°C at the bottom. If the liquid nitrogen level is not properly maintained, specimens near the top of the tank may rise well above -130°C. When multiple specimens are stored in a freezer box or on freezer cane or rack, removal of each specimen transiently exposes the remaining specimens to a near ambient temperature. Using a Cryoguard Thermal Exposure Indicator in each freezer box and on each freezer cane or rack ensures when the indicator is green that the efficacy of your stored specimens were never thermally compromised by nitrogen depletion or repeated transient exposures to a near ambient temperature.
Use of Cryoguard Thermal Exposure Indicators might have reduced the heart breaking loss of frozen eggs caused by depletion of liquid nitrogen coolant at the Ahuja Medical Center Fertility Center in Cleveland - had the center been using Cryoguard™ Thermal Exposure Indicators in freezer boxes to identify and salvage specimens that escaped potentially damaging thermal exposure. Additionally, Cryoguard Thermal Exposure Indicators could have provided an early warning of liquid nitrogen depletion when the alarm system was turned off at the Ahuja Medical Center.
Cryoguard Thermal Exposure Indicators provide assurance to you and your clients that your products were never thermally compromised. Join the leading hospitals, fertility clinics, stem cell labs, universities and aerospace companies who rely on Cryoguard indicators to ensure proper handling of heat-sensitive materials. Try a Cryoguard Indicator today!
Cryoguard Thermal Cryoguard Freezer Box Exposure Indicators
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M-70 Indicators For Cryoguard customers
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We deeply appreciate any feedback that you can give us regarding your experience with the indicators and how we might improve the indicators to better meet your needs. Please place your feedback in the customer comment box when you place an order or send your feedback to customer_service@cryoguard.com.